3300029217: Human fecal microbial communities from Rheumatoid Arthritis patients in China - RSZAXPI002661-50

Overview

Basic Information

• IMG/M Taxon OID: 3300029217
• GOLD Reference (Study | Sequencing Project | Analysis Project): Gs0127425 | Gp0192943 | Ga0168678
• Sample Name: Human fecal microbial communities from Rheumatoid Arthritis patients in China - RSZAXPI002661-50
• Sequencing Status: Permanent Draft
• Sequencing Center: Beijing Genomics Institute (BGI)
• Published?: N
• Use Policy: Open

Dataset Contents

• Total Genome Size: 149818943
• Sequencing Scaffolds: 23
• Novel Protein Genes: 28
• Associated Families: 26

Dataset Phylogeny
Taxonomy Groups	Number of Scaffolds
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	20
All Organisms → cellular organisms → Bacteria → FCB group → Bacteroidetes/Chlorobi group → Bacteroidetes → Bacteroidia → Bacteroidales → Bacteroidaceae → Bacteroides	1
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → Faecalibacterium → Faecalibacterium prausnitzii	1
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Actinobacteria → Actinomycetia → Bifidobacteriales → Bifidobacteriaceae → Bifidobacterium	1

Ecosystem and Geography

Ecosystem Assignment (GOLD)

• Name: Host-Associated Microbial Communities From Gut And Oral Samples Of Rheumatoid Arthritis Patients In China
• Type: Host-Associated
• Taxonomy: Host-Associated → Human → Digestive System → Large Intestine → Fecal → Host-Associated → Host-Associated Microbial Communities From Gut And Oral Samples Of Rheumatoid Arthritis Patients In China

Alternative Ecosystem Assignments

• Environment Ontology (ENVO): Unclassified
• Earth Microbiome Project Ontology (EMPO): Host-associated → Animal → Animal secretion

Location Information

• Location: China: Beijing, Peking Union Medical College
• Coordinates
  • Lat. (^o): 39.911947
  • Long. (^o): 116.4156125
  • Alt. (m): N/A
  • Depth (m): N/A

Associated Families

Family	Category	Number of Sequences	3D Structure?
F026592	Metagenome / Metatranscriptome	197	Y
F029444	Metagenome	188	Y
F032286	Metagenome / Metatranscriptome	180	Y
F039147	Metagenome	164	N
F042910	Metagenome	157	N
F043413	Metagenome	156	N
F045105	Metagenome	153	N
F050793	Metagenome	145	N
F051934	Metagenome	143	N
F051935	Metagenome	143	N
F055739	Metagenome	138	N
F058154	Metagenome	135	N
F062845	Metagenome	130	N
F068856	Metagenome	124	N
F070133	Metagenome	123	N
F072366	Metagenome	121	N
F073573	Metagenome	120	N
F073574	Metagenome	120	N
F075480	Metagenome	119	N
F077320	Metagenome	117	N
F082714	Metagenome	113	N
F090515	Metagenome	108	N
F095494	Metagenome	105	N
F099451	Metagenome	103	N
F101191	Metagenome	102	N
F102166	Metagenome	102	N

Associated Scaffolds

Scaffold	Taxonomy	Length
Ga0168678_100011	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	293206
Ga0168678_100058	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	174430
Ga0168678_100095	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	148066
Ga0168678_100140	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	117655
Ga0168678_100197	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	95106
Ga0168678_100240	All Organisms → cellular organisms → Bacteria → FCB group → Bacteroidetes/Chlorobi group → Bacteroidetes → Bacteroidia → Bacteroidales → Bacteroidaceae → Bacteroides	86511
Ga0168678_100319	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	71649
Ga0168678_100396	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	57899
Ga0168678_100518	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	45676
Ga0168678_100567	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	41613
Ga0168678_100595	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	40257
Ga0168678_100666	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	35797
Ga0168678_100757	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	31647
Ga0168678_100838	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	28415
Ga0168678_101033	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → Faecalibacterium → Faecalibacterium prausnitzii	23230
Ga0168678_101207	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	19681
Ga0168678_102267	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	9162
Ga0168678_104241	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Actinobacteria → Actinomycetia → Bifidobacteriales → Bifidobacteriaceae → Bifidobacterium	4511
Ga0168678_104357	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	4382
Ga0168678_106357	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	2928
Ga0168678_116999	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	1147
Ga0168678_123022	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	854
Ga0168678_127201	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	719

Sequences

Scaffold ID	Protein ID	Family	Sequence
Ga0168678_100011	Ga0168678_100011225	F095494	MQYHIVKGGFFVSDPKEKEVQAILQAIDYGHLPPRETQRRLLNIIQAEAARTDAPTDETKIHTCMDLLERLQGEQKPIAPARVDALRQHIAAAHQKNERKRQKRKKIIAAAACSAAAIAVAFAVSHPLLWYENWTTSDEQQHFVTSHEIAIEMLETAVADPMLPTDDTVEVQSIAALDALIGRKTGIPEMVNGQWELQHRYVNFTRSGISISLMYVNAADAQQTIVGVINLISNPQYMMLSFEQSYEGTIQQFDGLNFYITENINKPVALWQGDDKLLLFSGRTSQEEVTSLLRTIIREMGE
Ga0168678_100058	Ga0168678_10005825	F082714	MVVGIRFAADAPVRTVLQAVLPIFPTADVDFLVREYWVCTFGNGLPERRFTAQEMRRAVDALTPDEHAELFTIYVLPHDAPDTPPSSCEDFCARGFTMAFYAYDGDGYALLAQSEEQVEAAFEALTTAGLCEKVEEVEKETLAHWGF
Ga0168678_100095	Ga0168678_1000952	F051934	MGLMRRLAAAALAAVLVLSTALGERVTFRLSADIDPVQYPAQERKLAQGLKSLFRLLTVEGDVVASDGSFDARIDLGLTNAPEKTATRIRFFGLDSHWGIQATDLGGETLMVNQLAWLEFAIKAYNHLDLPLQRVFLWLSPYAHTSAWAGVRQAIADLTAQENDGRLENTALIACAEEIARLSEDDRALYYYIEAFGLESGADANIFDALATLPEYVEANFPDGLSIEHTENGVSWQNGEETVFSYAEADGTQVVSLHFPDLVDFSATLRRDALLFTGALSLQSDVLNAQVSFSLPVSYPVTLPFYAQIDADGMIAGDDGIHLAFEGEAQGDTITIRRIQPDHSATMMTLTVKVIQVAEGTVKYAPEDVQGTNVLSVDGPALAELMGRIGKPMVRKVTQWLAALPAELVQGAMDAMEDSGLLGTLTDAILNGEAGEY
Ga0168678_100140	Ga0168678_1001403	F043413	MTERELREKLQFAYGTMPDATRAAFEHSLTHHRVETRNPVRMSRRMRTIVTLALMLMMLTAVGVAAAKLASVTDYPPPSGLTPEYMSHLVALNEAYDGDLLTLSVNDLVFDGTTVEVAMNVQPKAGKQVFMDMEVTAECAGRAYTLEIEGCGGGDFMSGMFLPDETDSWSDSPFAFDGVLWDDDMQSPPEGVPIAWTMTFELLQPVWEVEYLPDAQYQALLAGGADTLEAYVQNNWRQHIITVTYGSLVEYQYAAEAAMLADGNITEPLSGSRTEQLLSCGGFRRADTIIVQFTTDFADDYAHPELVGKRIGMGDYDLVIDNVNLSFMRANITMHYEFSAAYTEDEIRQMTNLPNAWRVYVNGQTEAGYDAYANFQQVTNGAYGVDTPEQLTVGFDFYPAETDITRLTFVPIRNMGEKWDTCHPDAEKGFTLELQE
Ga0168678_100140	Ga0168678_10014037	F102166	MKKLFSLLLVLALALVPTLSLADDDAACQNLYNMLLDELKSVNLEMTADEESYRIYLGYALDKNSLGDADVIFDAYSDAVTINVSYSNPLDEALVPQVISFFNRVNSTLYVGKLMVIKSDNVWYAAYEIFLSVDPENITDWDRNNVLAYTALALDTMGEMVDYITEIANGESADNVFAMWQADIGAV
Ga0168678_100140	Ga0168678_10014042	F068856	MKRLTSILLALLMLVGMALAEEKSDAALGDWYALNTENEAICLTLREDGTFCYDSREGTWRKNEDGEYLLSYNNSAPSLLELLDGIGDWDDWEAPEADMTARLTETGLDVSYYGSPEGMVIHMVRDAEELQNVRKPKTDTPLEAFAGTWTMETVFAGAMQMTYTPDKGERLAFCTIDGLTMLPGAALGNFTEGTSYPMTLEDGKLHTTILMQMTEEETLDFDMTFFQTADGSLYATLRLSDVPDNPTTMFLLIPME
Ga0168678_100140	Ga0168678_1001405	F055739	MTEQQLREKLQFAYGTMPDATRAAFEHSLTHHRAPETHRSIGLNRTMRIVITAVLMALMLTAVGVAAARFFSVTDVHPAQDGTEGDYQAHYLALEERYDSDLLSVSVNDAVYDGSVLAFTMEMAAKTDDVLAVEVRVRGECDGKMYRFDPLDVYGGEFQSLLMLPDLGGTFDGEKYAAEGILLDENGQMPPEGKPIAWTIEIDVLKAVWQTETMPDDLYEALSEEDDVAQYIREQAEQHMITLTDAGVEDYLLEMCGAGWDEIEQMSKADLLLRCGGFERAETYTVAFATEGNTQYVHPELSGLRIPLDGYTAVVDYVRASFLGGCVVLHCEAPNGTALPNGTALPDVWRVYRNDEQNPAGEAGWARASGYAGVPGGVVDVNQPSICLYFAPCADLTSLRIVPEGEAGFTLNLSGEKGTE
Ga0168678_100197	Ga0168678_10019717	F075480	MNKTKQEKWQRAYGDTPDSFRQRVAASLPKGQETRHVAFPRRAMVLAAALVLVLTTAYAAVVTHTELVWNAGHPIENEADDRLGLLTGEAGTSGDSLTIGGVTFTVQDGVYSPENGQLFASAVISADESVQLVAVEADMEHEVRLTTPVDAKLDPSGISWAEWAEQNAKTLVPIGMEAAPTLQFLKVNGQTTDTPLIGAFLTQNPDGTVSAGFQVDLSEADVSHLKSCEVQLECRVGAFGKDGKATQWQKEILTATITFK
Ga0168678_100240	Ga0168678_10024046	F099451	MEIKNVGKLRKIIENLPDDFEIEIRIRRKLTDEELKNCRYPYPYDTEYLILEFDDLGVSSKVLCLGVTYNE
Ga0168678_100319	Ga0168678_10031934	F058154	MKNRTFQRLFPFLRMGSILLAAVLFCAALIGVNAQLTVGTNEERNLATYLGLALTAVVTYLLQDVPKMLVGRHFGWKLVRYEAFGRVYQADGTGAFVRVPVPAQSRLRYQPYLLPPEDASRHDVTLYTLCPLLYGGALAVVFGVLTLLTLGQPVSLVLCELAMGGVVLVMTCILPMDERFIASPMAIARMLRDPEQLAEWLYFARMKANGGVEVTDVSIENIPQPATVKTCQDAICVFQRAQIALMVQCDAQKAYGLMKQVLESEARLSYTAWKLLLSDGVVAELLAGEPGEFTALYRGKAGAAIRQVMFRMVDYALPAYAVATLVTHEAREAEVVRNTLAPVREKMPELDALMKAIEEKAARIES
Ga0168678_100355	Ga0168678_10035547	F045105	MSDKLKRVLDTNLAGLHVTDAQVNAVLRRVSQDEKRPRVIRWQAIAAVLLVLVLGAGVLLQTGILSDDSPQLTADVTRQGDFLTAAQVKKLLASAADLQFSVDEEAISALMTQVEKDGGCSLSTLLEILCPAGSSLGQWDIRAQVALSQTLERIGYQGILPGMTREPLSTEITAQDALARAVAYIRTNDDPQADFTNLDFYRVGIRFLSGVYDGTCEGAYYCVNFDALDAFGTTYEVAVNAEDGSICRMRRERGAGSNHTADEVTRGFRRIFGYDMRTWTPMQLRVYILALSRADRSSMQTVHELFLSVGRDGFPDVPAEALTREEAIDAALAIQGGSSSDVLAAEYLAGASSDFWKIAIRQPNAPSGQSIVYLELNGLTGTLLTTTYSGNLYGLPQEFFPSQLLSTLDRTDFSHGVPAVDAETAQSAASAAIERQYQRNMAEEGYTCFIESDFEDTAGGFSYYTGGGVVIFTKDAQNTSQGDIYWAALNWYGEVLDVGWNRNPLDAARFTLLMQGFLPPKYCSDEVLQLQALLTGSQTDEAGLRQMETDGTLPLFNALLALEVVPDASTKSTADDVTAAALKSLNAHLCYENSSFLVYREDGELIWHFWLSTDMGYFLMDVRDSDLSVVGSVQIPSFSALRASILLPVRVWNTLAENLRVTIFYRDANTQPGIVYGMYANHIVQRYVDLYGANILRWDQATLRSFQSAISISGSYVGDWSVACLCQTIYPDVPDYAISQEVAAEYAARALGDDDYSLRGGVLIDPGEGDPIWKVTLDYPDGRSFNAEVDCRTGAIRTLRQQDTRVMPFYTDYLDFPDDGEYWFRNFVLDEVIEQVRTQMTGRYGNNV
Ga0168678_100396	Ga0168678_1003965	F073573	MPTIVSFYQRFPNEAPPLNLSAFDHTGYTYAENFRRNERCYEAEQCEVTSDDGSVVLSLDVRIRPRGGEIEALPRVMLSVYSEGVLFQVRRMELRTGDTTYAILPDNVQQYTKRGDTDGGFLETMAIPLGKVGMKMLLEASDAAEARWVIQGARTAQTLPLTAAQKKAIRRFCMDCEESAITYQPAFLWYKDYCTKA
Ga0168678_100518	Ga0168678_1005182	F077320	MKHKGMHRRRKLVLLAVLLIMVGIAVWRIWQTPRPTVLHRQDAWLSSAEPEMVDTLPDNAFTAELPEEIDGRLLYIRDYSASGHYQIVWENVSAEAAESYLTALLDEGFTRLMGTAEDIASGVLLARGDLTLSISLSGGTLNMLMTRAEEPTATPLPEWLADW
Ga0168678_100567	Ga0168678_10056724	F032286	VTPVRHRALVFDARLSAGNTANDTLVTGGTFRFCRLMCLCVKRRNIILNGKRHLLLNSALFRADSHTVQKTISPFSLALILTFDFAALSERRSCPEDRSRRIVLLGALDAALRWGTYPVRTVMQFSRFRCDCKTILAKNIALSRISKRSENAPKNTDFHAYGQDRKRAGI
Ga0168678_100595	Ga0168678_1005958	F072366	MLDILAIKADVYQLERQGKRLPVYRYLREVWQKEPPSEGLTVLALQQMVDYVEYVDDLTVLGEPWEAENEYDLYQDFLLDVISWGLQKYRAKKRFLWQICYYVNAWATFYYIFGREITQDNVEQWTKTLFEEAKERYPDSMLFEFIPHAAQLDYVWFYRLTDEQRLQIRLEVGEWNLQKNDMDQAVQSDFDDAMTWYRDNGRKLLEAKNKTNN
Ga0168678_100666	Ga0168678_10066613	F039147	MRARRLLILLMMLLLLPQAQAERLTLYTRPGQVDEATPFQLRPTELSICSVTRAMGGVVLLANDDNYDSLSLYFWQDGMTEMRKLGGGFYWVMSSDTMETAQESCEYSMSRVPNYRMPDLTHAISNLTSDGETLYALNRINGLIFKISETKDGLQTEDVCTMENLSCLNISYRDLETDKVYTYPASLTRMYVCGSVLAISVMQENGIKVVLVDLTDGAIREIAGESLEAMYEWADGELLLWRLEGSPNEISRSSGTYTLSRYSVATGEETLLSTGVPYKKRSECGAYDPYSGSYYDVRTRQIVRTTDFVQEEPVVTFPAANVDIAVTKDSIVGVNRSSVYVRSKENGNMTVLRIQSSNGASNTALQHFAEENPEVILAQETLTKSAMNAASLAARMSASADAPDILRLGLTPDTPEADGSWPLDVLMDKGWCMDLSIYPEVSDYVPRMNEIYRDAVTRDGKIYALPIYAWSYGYFISRNVMEKLGLQESDIPTNLIDLCAFITKWNDNLTGAYAAYTPLEETESYRERVFDLMVRDWIGYCQAENIPLRFDHPVFREMMAALDAMRTDKIEQANQQVNEEISDYRECLIWTDAQAVGNFANYADAFGSRIFLPMALTPDVTTHYGIGYMTVLVVNPRTTNADLVGKMLAQVIADQEATAKCVLLADYDEPIEDSYYLTMVSDYEKTLTELRRQQENAPAWKKQGIQERINEEEASLQRYTVRERWTIAPKTIELYQQTILPMSYLRRPGILADSDAFNALVSQVHQGEISLEEFVEEADKLIEGLEQ
Ga0168678_100757	Ga0168678_10075719	F050793	MRKYEVLVPENVEMADIHAIQTRVKKHNLLTVALLIPLFAGYALRESSETLGGIVFVLSIALMVLGFISGRGDEKRLPAYWAKHQQIHRMDNLLRANLVGVWLCAEARVAVYREGSGYRVQLDVLNEKTGAWENDEQDEVFPTLADVREYATQEGYEPMDVDFGQMTDEEFQQFLDRSRI
Ga0168678_100838	Ga0168678_1008387	F101191	LLISHHPASAECLQLGEGMLLCGFDLDKALSSRDPLDCMAEAVADDTKRIGTTCGGGIFRAVPREFDPESGSHRLPFAGSIRLIDWRVTLSGTMLDVTPENLARLLPSDTEITERVTTLTPKQARKPLSRLCWIGTTSRGLLLIELRNPLCISGASLTSVPDGAGRLPFTFLAQNDRPGDVNLPARLYWWKEETHDAA
Ga0168678_100838	Ga0168678_1008389	F042910	LADRLYCALNGTTLHDLDARIHLLDVEELAPAVRTVTASRIGGGLHLLRRQREQLSLRVRFLIEEYDIAARHQLLHLVAAWAEAGGVLTLHEDGKRVLRVVCTQFPAMSTLNWLETLSLVFTAFSCPYWEDAAETSFLMPNTSDAPSKLLAVPGDAPETPLNLLIRNIGDTAITTLTISAAGKISFQGLTLAPGAAIRIHHNAGVFAAEMVSNDSTVSILPYRTPESADDLLLRPGVLNEIRVEASAAAFVSGRCKGRYC
Ga0168678_101033	Ga0168678_10103323	F062845	MEKTPFILHEKFRSDNNEQRKEHFQKKFERYIVDSLSDTAPSKSCA
Ga0168678_101207	Ga0168678_10120716	F090515	MIRSIRGACQESVTTCCKAGPKAALQGTAPGRVACLEFAGGEKRKTNIAADYAVKVPAFTALLCRHIGSIRTFLKS
Ga0168678_102267	Ga0168678_1022672	F073574	MLLPAAVRPYAADADGTASRVRCAIALNGSKELHIQLCGRLKRGLFGRNQLLADGDVLCVALHQPDGDVPLFDSRCDGYANVLDDRQPPAPIPLHPAICPKCRNAAFQLRLTFEYPEAEELAAFANPDNMFTWVWLSLRCTRCHAVFRGDFTAD
Ga0168678_104241	Ga0168678_1042412	F032286	VTPVRHRALIFDARLSTGNTADDVLVTGSTFRFCRLMCLCVKRRNIILNGKRRSLLNSTLFLADNHTRQKAISPFSLALIFTFDFAALSERRSCPEDRSRRFVLLGALDAALRRRTYPVRTVMQLSTSHESPSQLRMKHRWPGAARPAAV
Ga0168678_104357	Ga0168678_1043575	F070133	MKRLLGLLLAVMVMMGGMAGAQASTDNASMQLIRMNPLAFRKEPVELYSVTHTPNGSFVVIYFAEGEKTELQEMWMELFDSVGTSLLSAKLGKFDPNGEQIPHGQIILKKNRFICEYYPDITSMEVCTQTVYRYTGKRIQKPTTKKLKFGAAPYAQHVGDYMVEKQAHSEDETPFRTVKITHIASGKSKKLMIYDWSFCAFPDQDGNLLIAQQNEKGNLEIRSYNAAMQESIVELNGDFLQNENVRDAACIGQTAYMRIRLTNEKSEILLYDITQQKITDSQTLLAVDDNSYIAEIKAAGAVLLSVDGYWNRELQRQKYQINLLNEHFETSRLPLQHESCLYIFTDVEQADITTIEMDEKSHSYFVCSYSISAGE
Ga0168678_106357	Ga0168678_1063575	F026592	RTASPQGIAALAAQGGVATLTERSDETFSVGQFSSADWE
Ga0168678_116999	Ga0168678_1169991	F051935	MKRLLGLLMAVMVMMGGISCAVAENANPIVSDWLTELKSKRLIQIVEDEIGEGWTLYQPNGREEEENFSSAENLKEMRFLPVVAQKDNQLRLLILRRQGDLWKVSEQNDRALMRDGWTLQNFSAMPYGNSDWTYIFFDFVDENQKRWELMLNLGDGYVSSFDAISYYVEGYGTTYINMNYDRGLEFLIDAPAYSRLSYEVYPVEDYSFGVEDFDLATCPLSMQEFLVSAIVTCGEEGAGLYIMVQQDAQPTVMLTDGDTIEAIPQKWELDWTIVYYQGNYLFMKTENCKMEE
Ga0168678_123022	Ga0168678_1230221	F062845	KTPFILHEKFRSDNNEQRKEHFQKKFERYIVDELSNTALSKSCA
Ga0168678_127201	Ga0168678_1272014	F029444	MEFSEQLTGFELEDLMPWTVSNLQRPFRDDFSLEKSGIIAEKESQIFGRRFVGFDGPKKAAPFFNF