3300029603: Human fecal microbial communities from twins in the TwinsUK registry in London, United Kingdom - YSZC12003_36056

Overview

Basic Information

• IMG/M Taxon OID: 3300029603
• GOLD Reference (Study | Sequencing Project | Analysis Project): Gs0133139 | Gp0283775 | Ga0245139
• Sample Name: Human fecal microbial communities from twins in the TwinsUK registry in London, United Kingdom - YSZC12003_36056
• Sequencing Status: Permanent Draft
• Sequencing Center: Beijing Genomics Institute (BGI)
• Published?: N
• Use Policy: Open

Dataset Contents

• Total Genome Size: 188138562
• Sequencing Scaffolds: 23
• Novel Protein Genes: 27
• Associated Families: 25

Dataset Phylogeny
Taxonomy Groups	Number of Scaffolds
All Organisms → cellular organisms → Bacteria	1
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	13
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes	1
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → Ruminococcus	1
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae	3
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → Subdoligranulum → Subdoligranulum variabile	1
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → Faecalibacterium → Faecalibacterium prausnitzii	1
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → unclassified Oscillospiraceae → Ruminococcaceae bacterium LM158	1
All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Clostridiaceae → Clostridium → unclassified Clostridium → Clostridium sp. ATCC BAA-442	1

Ecosystem and Geography

Ecosystem Assignment (GOLD)

• Name: Human Fecal Microbial Communities From Twins In The Twinsuk Registry In London, United Kingdom
• Type: Host-Associated
• Taxonomy: Host-Associated → Human → Digestive System → Large Intestine → Fecal → Human Fecal → Human Fecal Microbial Communities From Twins In The Twinsuk Registry In London, United Kingdom

Alternative Ecosystem Assignments

• Environment Ontology (ENVO): Unclassified
• Earth Microbiome Project Ontology (EMPO): Host-associated → Animal → Animal distal gut

Location Information

• Location: United Kingdom: London
• Coordinates
  • Lat. (^o): 51.5
  • Long. (^o): -0.12
  • Alt. (m): N/A
  • Depth (m): N/A

Associated Families

Family	Category	Number of Sequences	3D Structure?
F013656	Metagenome	269	Y
F029444	Metagenome	188	Y
F032286	Metagenome / Metatranscriptome	180	Y
F039147	Metagenome	164	N
F041208	Metagenome	160	N
F042936	Metagenome	157	N
F043413	Metagenome	156	N
F043945	Metagenome	155	N
F045105	Metagenome	153	N
F047126	Metagenome	150	N
F050793	Metagenome	145	N
F051935	Metagenome	143	N
F052660	Metagenome	142	N
F055739	Metagenome	138	N
F059982	Metagenome	133	N
F067845	Metagenome	125	N
F068941	Metagenome	124	N
F073574	Metagenome	120	N
F074898	Metagenome	119	N
F077319	Metagenome	117	N
F077320	Metagenome	117	N
F078822	Metagenome	116	N
F087213	Metagenome	110	N
F089005	Metagenome	109	N
F096287	Metagenome	105	N

Associated Scaffolds

Scaffold	Taxonomy	Length
Ga0245139_100022	All Organisms → cellular organisms → Bacteria	296681
Ga0245139_100043	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	237683
Ga0245139_100172	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	111365
Ga0245139_100189	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	106260
Ga0245139_100213	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	97282
Ga0245139_100215	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	97179
Ga0245139_100238	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	90646
Ga0245139_100264	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	84470
Ga0245139_100265	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	84285
Ga0245139_100356	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	62586
Ga0245139_100372	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes	61109
Ga0245139_100456	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → Ruminococcus	49290
Ga0245139_100515	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	43064
Ga0245139_100873	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	24521
Ga0245139_101377	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae	14931
Ga0245139_101554	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	13128
Ga0245139_102403	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae	9014
Ga0245139_103508	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → Subdoligranulum → Subdoligranulum variabile	6609
Ga0245139_103551	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → Faecalibacterium → Faecalibacterium prausnitzii	6541
Ga0245139_108161	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae → unclassified Oscillospiraceae → Ruminococcaceae bacterium LM158	3344
Ga0245139_114247	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Oscillospiraceae	2055
Ga0245139_124794	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales	1214
Ga0245139_128720	All Organisms → cellular organisms → Bacteria → Terrabacteria group → Firmicutes → Clostridia → Eubacteriales → Clostridiaceae → Clostridium → unclassified Clostridium → Clostridium sp. ATCC BAA-442	1041

Sequences

Scaffold ID	Protein ID	Family	Sequence
Ga0245139_100022	Ga0245139_100022282	F068941	MKNNKGLIIGIIGLIIVMIGGTYAYYRWNSTSNINVSVKISGNTVTFVGGSNVTGTLTPVDSKEKGIKKDITVKASEAGSTMSLYMELTTMPNELKEESFIYELYYNDTTLVKKGNFKAYNASSNASGITYASSGVTTLTLFTDRNVNTTTDKYTLYLWFNGKDFTNPNTMQNKTLSFNLYATGKNARLNG
Ga0245139_100043	Ga0245139_100043124	F077319	MLIRNATLQMSATERACMDVRVMNGCVWEMGAALVKGLYESETDLCGDVLMPGRMLETPIPAADEKALRLLCRRLYREGVRYFVADCPADALLRVQNRPERRGALPVTTLPNPEPLRSGTGMPLTRWTAAGEFVGMMDEHSGD
Ga0245139_100172	Ga0245139_10017241	F096287	MQRIQKRRAGQRQTQNALIGLLSAVSMTRIGLTQLLPLCGSAAWWLSAACMLPGLCVYGAFRLLLRHTHTRTLTDCARKLLGNFGIILIMLTLTLPLLLDGIASLTALITFFTEGIGARGSQFTLTLLTASVMLIALNRDGLPRGVYLLRHVLLVAAAIIAINALLDAHPDGIVPLLGEGVPPLKNGFRSSWGMSWMLLLLLEFPAEEGTRRTPAMFVALLPCPVILLLLSLSIPPELTVPGRSLASRLALPTLFLQPAVRTLAQCLLMMTLFLSIAGSAQLAARFLTSSCQKPKKWVPYALIGLLTLTQLFDISRLWRVLTALTAWSLVPGVLLLLVLTIARLCRREKA
Ga0245139_100189	Ga0245139_10018975	F043413	MRTIVTLALMLMMLTAVGVAAAKLASVTDYPPPSGLTPEYMSHLVTLNEAYDGDLLTLSVNDLVFDGTTVEVAMNVQPKAGKQVFMDMEVTAECAGRAYTLEIEGCGGGDFMSGMFLPDGTGSWSDSPFGFDGVLWDDDMQSPPEGAPIAWTMTFELLQPVWEVEYLPDAQYQALLAGGADTLEAYVQNNWRKHIITVTYGSLVEYQYAAEAAMLADGTITEPLSGSRTEQLLSCGGFRRADTIIVQFTTDFADDYAHPELVGKRIDMGDYDLVIDNVNLSFMRANITMHYEFSAAYTEDEIRQMTNMPNAWRVYVNGETDSGYDAYANFQQVTNGAYGVDTPEQLTVGFDFYPAETDITRLTFVPIRNMGEKWDACHPDAEKGFTLELQE
Ga0245139_100189	Ga0245139_10018977	F055739	MTEQQLREKLQFAYGTMPDATRAAFEHSLTHHRAPETHRSIGLSRMMRIVITAVLMALMLTAVGVAAARFFSVTDVHPAQDGTEGDYQAHYLALEERYDSDLLSVSVNDAVYDGSVLAFTMEMAAKTDDVLAVEVRICGECDGKMYRFDPLDVYGGEFQSLLMLPDLGGTFDGEKYAAEGILLDKNGQMPPEGKTIAWTIEIDVLKAVWQTETMPDDLYEALSEEDDVAQYIREQAEQRVITLTDAGVEDYLLEMCGAGWDEIEQISKADLLLRCGGFERAETYTVAFATEGNTQYVHSELSGLRIPLDGYAAVVDYVRASFLGGCVVLHCEAPNGTALPNGTALPDVWRIYRNDEQNPAGEAGWARASGYAGVPGGVVDVNQPSICLYFAPCADLTSLRIVPEGEAGFTLNLSGEKGTE
Ga0245139_100209	Ga0245139_10020946	F045105	MSDKLKRVLDTNLAGLHVTDAQVNAVLRRVSQDEQRPRVIRWQAIAAVLLVLVLGAGVLLQTGILSDDSPQLTADVTRQGDFLTAAQVKKLLASAADLQFSVDEEAISALMTQVEKDGGCSLSTLLEILCPAGSSLGQWDIRAQVALSQTLERIGYQGILPGMTREPLSTEITAQDALARAVAYIRTNDDPQADFTNLDFYRVGIRFLSGVYDGTCEGAYYCANFDALDAFGTTYEVAVNAEDGSICRMRRERGAGSDHTADEVTRGFRRIFGYDMRTWTPMQLRVYILALSRADRSSMQTVHELFLSVGRDGFPDVPAEALTREEAISAALAIQGGSSSDVLAAEYLAGASGDFWKIAIRQPNAPSGQSIVYLELNGLTGALLTTTYSGNLYGLPQEFFPSQLLSTLDRTDFSHGVPAVDAETAQSAASAAIERQYQRNMAEEGYTCFIESDFEDTAGGFSYYTGGGVVIFTKDAQNTSQGDIYWAALNWYGEVLDVGWNRNPLDAACFTLLMQGYLPPIYQRETVQQLQALLTGGLTDEAGLRQLETDGTLPLFNALLALEVVPDASTKSTADDVTAAALKSLNAHLCYENSSFLVYREDGELIWHFWLSTDMGYFLLDVRDSDLSVVGSVQIPSFSALRASILLPVRVWNTLAENLRVTIFYRDANTQPGIVYGMYANHIVQRYVDLYGANILRWDQATLRSFQSAISISGSYVGDWSVACLCQTIYPDIPDYAISQEVAAEYAARALGDDDYSLRGGVLIDPGEGDPIWKVTLDYPDGRSFNAEVDCRTGAIRTLRQQDTRAMPFYTDYLDFPDDGEYWFRNFVLDEVIEQVRTQMTGRYGNNV
Ga0245139_100213	Ga0245139_10021345	F077320	MKRKGMRRCRKLVLLAVLLIMVGIAVWRIWQTPRPVVLHRQDAWLSSAEPEMVGTLPDNAFTAELPEKIDGRLSYIRDYSASGHYQIVWEGVSAEAAESYLTALLDKGFTRLMGTAEDIASGVLLACGDLTLSISLSGGTLNILMTRAEEPTPTPLP
Ga0245139_100215	Ga0245139_10021521	F039147	MRARRLLILLMMLLLLPQAQAERLTLYTRPGQVDEATPFQLRPTELSICSVTRAMGGVVVLANDDNYDSLSLYFWQDGMTEMRKLGGGFYWVMSSDTMETAQESCEYAMSRVPNYRMPDLTHAISELTSDGETLYALNRINGLIFKISETKDGLQTEDVCTMENLSCLNISYRDLETDKVYTYPASLTRMHVCGSVLAISVMQENAIKVVLVDLTDGAIREIADESLEAMYEWADGELLLWRLEGSPNEISRSSGTYTLSRYSVATGEETLLSTGVPYKKRSECGAYDPYSGSYYDVRTRQIVRTTDFVQEDPVVTFPAANVNIAVTKDSIVGVNLSSVYVRSKENGDMTVLRIQSSNGASNTALQHFAEENPEVILAQETLAKSAVNAASLAARMSASADAPDILRLGLTPDTPEADGSWPLDVLMDKGWCMDLSVYPEVSDYVSRLNGIYRDAVTRNGKIYALPIYAWSYGYFISRNVMEKLGLQESDIPTNLIDLCAFITKWNDNLTGAYAAYTPLEETESYRERVFDLMVRDWIGYCQAENIPLRFDHPVFREMMAALDAMRTDKIEQANQQVNEEISDYRECLIWTDAQAVGNFANYADAFGSRIFLPMALTPDVTTHYGIGYMIVLVVNPRTTNAELVGKLLAQVIADQEATAKCVLLADYDEPIEDSYYLIMVRDYEKTLTELRRQQENAPVWKKQGIQERINEEEASLQRYTVRERWTIAPKTIELYQQTILPMSYLRRPGILADSDAFNALVSQVHQGKISLEEFVEEADKLIEGLEQ
Ga0245139_100215	Ga0245139_10021533	F051935	MKRLLGLLMAVMVMMGGISCAVAENTNPLVSDWLTELKSKRLIQIVEDEIGEGWTLYQPNGREEEENFSSAENLKEMRFLPVVAQKDNQLRLLILRRQGDLWKVSEQNDRALMRDGWTLQNFSAMPYGNSDSTYIYFDFVDENQTEWELVLNLSTVYVSYFRMIYNAEGYGTTEIVFNYDHGMKFQFDAPFYFRLSYDVDPAERYSFVVEDFDLATCPLSMQDFFVPAVVSCGEEGAGLYIMAKQGIQPILVLADGEMIEAIPQRWQRDWVIVCYRGNYLFMKTENCKMEE
Ga0245139_100238	Ga0245139_10023863	F074898	MRKILSLLLILALFLPCALAETPQGIDLALTSTYGDGLSLRMTAGLGETPFCSLTLPSGQIDLAFSPDKGLCVQSGGQWAQLLVEGHPVDAALLTTPLKLLDGRSPSEVLGLLAEDVNKMLDAIPSLYNLPMTLIRDPAFARLFSDLYIAAQTGTISITSEELNRMAASVLGKIYSMEYLDGLNFSDIYHHLLASVVQSSEVARAYRSAMRGYLLSNFRLSGQIGIDKGELLFSQPYQEPYHLTYEQTTPNSWHYLLTTANSDTIDGVLYWRNEYDFALSGYSENQHTAFSVTCSYGSANNFVFIASVDNSFSLSIVQAGSNFSLRLNNENANVFALNANVFSLESTSDYIRVKIYYNYYTLTITPATDGLDIVAQARTFDIFTAHVRTALNGLICTGVYGDTTYRLALTETATGFSLLLSLPDGDFHLDFAALSDTSCSLTFTDAAGQQVSLTGSLCTPESPVIPEAIGTIELTQLLDGLF
Ga0245139_100238	Ga0245139_10023867	F073574	MLLPAAVRPYAADVDGTASRVRCAIALNGSQELHIQLCGRLKRGLFGRNQLLADGDVLCVALHQPDGDVPLFDSRCDGYANVLDDRQPPAPIPLHPAICPKCRNAAFQLRLCFEYPEAEELAAFANPDNMFTWVWLSLRCTRCHAVFRGNLECD
Ga0245139_100264	Ga0245139_10026451	F041208	MRKILAMLLSVLLLLLTAAVGETPAPYAPETVLPLVANNRPYRDFARGAISSSEDAIEQAKAWLYLPLFVTNFSAKSEAVDWSAMRAEEGWYVTAYMRNTFVWLLMDEQGRVQAYDFDLLGNASLTYDGALPDNLDEAIASYIRRFAELNGFVEVADYAREEVTTFGDYAVAVTVQVTLDGTPYRFTMRLDMMAFTSVENANLHPAAAQTQRDILLLMRDNLAEKGVDVAQTFFAVQADDADGETKLTGIASFPADAASDAIREQYGELERYTLHYSGRASEAGIERVELSDWQETTATAQFPLVLYALVDGKYLVPDGELAAGTAYLALDSMGLRGRNVIPLESITMLTRIRYARADGTFAESWVSSDTLTENDAAPAAPKREPIPTLESYQITLSGTAYTAFAINKVEKGYNAFADIAGTRMTVVDVLTSAAQGVIAEYGVDASDLLCRTVVEYGYRADKGCWQVDFTIPQRDMADDAYEVEVDDKDGKVTGMWGPQDGNG
Ga0245139_100265	Ga0245139_10026550	F059982	MRRMTRLLCLMLLFSLITFSCPLAEETDAPTGTPAPTPMLTAVPESALAPFNVVLPEDAHVEMAEGRITLVRGDSRVVAMVISRVPDDDPAAALPILMQDFDPKTSETMDFDAQPGFCILGGVVNDAFGDGEDKITLMVLADSGELLILSGYNLARDHHALYLFLTELLENVSMDGEAVYVAEDAAATASPEV
Ga0245139_100356	Ga0245139_10035615	F087213	MKKFFSLFLAVLLIFSCWTAATAESIDAVSGAPLDNDIEIVYKEHFDDMVTHYADELTEAELLVSADVYDAIGMIRFDSEDSLAARQRIYGIASADDLHAILTGYFDPNDAAYTADTALDARLQAILAACGLNPEDYDISVIRNLGGMIEPITGTNWYCTLIRKGVEVAEDETNPYDMVIVLYGDEMTVGAFVLNPEV
Ga0245139_100372	Ga0245139_1003723	F068941	MDNKKFIIGVALLLLLMLGGTYAYYKWSSSDNMNVNVKIDGGTVTFNGGSNITSTIIPTASKEEGIKKDITVKASKAGVTMNLYMDLTTMPDELKEKSFEYEIYYNSSTLVKKGNFGVYNSNTNTSGIAYATSGVTTLTLFTGRDVSTNSADKYTLYLWFNGKDYTNPNTMQSKKLSFDLYATGENAVLAGN
Ga0245139_100456	Ga0245139_10045639	F089005	LTKSKQCSTIALALLRLATSNEESKQALKVRRTLKIEQRENSKETRNDFEESSKNYSE
Ga0245139_100515	Ga0245139_10051519	F050793	MADIHAIQTRVKKHNLLTVALLIPLFAGYALRESSETLGGIVFVLSIALMVLGFISGRGDEKRLPAYWAKYQQIHRMDNLLRANLVGVWLCAEARVAVYREGSGYRVQLGVLDEKTGAWENDEQDEVFPTLADVREYAAQEGYEPMDVDFEQMTDEEFQQFLDRSRI
Ga0245139_100873	Ga0245139_1008738	F043945	MKHNLRMAFLSLLLVLTLGVMPVFAESADHAMDWTHGIGSRYRTDVTSALPFEDELFFISGSQLLRVDDPEYEPEVVCNLEDIIWSEALKQSGYYGQVMLLNGGAELVLFSANEGRLYSFVPPTDDTMVRMQMVTELDYSTVPQMGWKKFPIAKDLYDVTVEQAVYDAENGLYVIAKDKTDEYQIVWFDLDTGKGEMLEFALEDDENSHLLTDMPGFFRWSAESSKYERTLYDGKVLTTVDLSSGEATKAVHNWVNTLTLQPIPDYDVTLGDYVTHDAYYAYAPNKDNSAMYFVHDNTVWVMEYDEENSQFSEPRGIDKLPFFAEDTMCGFYWRGFYLIQTHDGLYLCHTGDETARAYLYGGVE
Ga0245139_101377	Ga0245139_1013771	F078822	DIFLSFPNAFSKAFHPHAVRFPAAFLLVHRFYLAFGELLSCATAYL
Ga0245139_101554	Ga0245139_1015545	F052660	MCILRVLPEKTSERIGQEWAGTEWTVVKSKIRLCIRNRSYGRFLHGGILMGIALSIPAHRAKSHDFACWWPAAADHSRSASALPGKSNS
Ga0245139_102403	Ga0245139_1024036	F047126	VYLKTKKMMNISQTQAGFKAKSLGILCGFQGFLTQNPAALVETDDIFDVSDTPYGFSGLNTLRAAGVPNPPSPFAQRFIACFCSQTAAAIQSKSAYILSFLESPCILCSLLRHFHILSKKLQKTC
Ga0245139_103508	Ga0245139_1035082	F042936	MGRGGGKGRVWKTKEGVMKTSGIVDRGEDTIRNFEKVEQEGALTPPYLGKVYFRSRLRGK
Ga0245139_103551	Ga0245139_1035512	F067845	MKHWKNLLVCLLAGVLALGVLTACSGLGSVNTGTDAEKAAELAQQLGVAHTQELDNTAKAVAEWFVQEPDSLRVSGLDLVYTVALDADGNMGYTDNLNHFLFWSGCYGVPENVTVALLLDDSTAMTAQLYAPQADSAAAELLKDAVGHSKMGAAFIDYNGTAYVVAVFR
Ga0245139_108161	Ga0245139_1081612	F029444	MEVSEQLTGFELEDLMSWTVSNLQRPFREDFSLEKSGIIAEKGAQIFGRRFVGFDGPKKAAPFFNF
Ga0245139_114247	Ga0245139_1142473	F052660	MCILRILPENTPEKIGQERAGTEWTVVKSKIRLCIRNRSCGRFLHGGILMGIALPIPSHRAKSHDFAHWWPAAAGHSRSADALPGK
Ga0245139_124794	Ga0245139_1247942	F013656	MEKKIYKEPNKSETETTINVLYSEQIINIYTNKVSLQKQLNKILGQPTNEYKIKRSIVGSCWEIPFKEKSKISQMILKANIYEL
Ga0245139_128720	Ga0245139_1287202	F032286	VTPVRHRALVFDARLSAGNTANDTLVTGGTFRFCRLMCLCVKRRNIMLNDKRRSLLNSALFRADNRTEQKTISLFSLALIFIFDFAALSERRSCPEDRSRRFVPVGTLTLSRSWRLLRWGTYPVRTVMQFSRFRCDCKTILAKNIALSRISKRSENAPKNADFHAYGQNRKRAEI